TO THE NOBEL COMMITTEE & ROYAL SWEDISH ACADEMY OF SCIENCES STOCKHOLM, SWEDEN TO THE SCIENTIFIC & ACADEMIC COMMUNITY AND MASS-MEDIA WORLDWIDE TO ALL AUTHORITIES IN ROMANIA

PETITION FOR THE RECOGNITION OF GHEORGHE BENGA, AS A DISCOVERER OF THE FIRST WATER CHANNEL PROTEIN IN THE HUMAN RED BLOOD CELL MEMBRANE, SEVERAL YEARS BEFORE PETER AGRE (2003 NOBEL PRIZE FOR CHEMISTRY)

In 1986, Gheorghe Benga and his coworkers discovered the presence and location of the first water channel protein in the human red blood cell membrane, several years before Peter Agre. In October 2003, Peter Agre was awarded the Nobel Prize in Chemistry, "for the discovery of water channels", jointly with Roderick MacKinnon. The Nobel Committee has neglected the important scientific contribution of Prof. Benga, without even mentioning it in the historical description of the discovery of aquaporins that joined the prize announcement.

This website supports the public recognition of Prof. Benga's discovery, providing pointers to documents that prove it. You are kindly invited to sustain Prof. Benga's petition addressed to the Nobel Committee by adding online your signature.

Quick facts:

• In 1986, Benga and coworkers clearly demonstrated the presence and location in the human red blood cell membrane of a protein involved in water transport and indicated the way to further studies, by purification of protein and reconstitution in lipid vesicles: "The binding pattern of PCMBS we have observed in correlation with the inhibition of water diffusion suggests that either or both band 3 and 4.5 proteins could be associated with water channels. Polypeptides migrating in these regions have already been identified in other transport functions, notably anion exchange and the transport of glucose and nucleosides [...]. To date, however, there is no evidence that a specific inhibitor of one of these processes will inhibit water transport. It remains possible that a minor membrane protein that binds PCMBS is involved in water transport [...]. We believe that the best way to clarify the role of bands 3 and 4.5 in water transport will ultimately be through studies on the reconstitution of purified protein in liposomes" (Benga et al., Biochemistry 25 (7), 1986, pp. 1535-1538).

• In 1988, Agre and coworkers isolated a new 28 kDa membrane protein, CHIP28, from both red cells and renal tubules. They suggested that "this new protein may play a role in linkage of the membrane skeleton to the lipid bilayer" (Denker et al., Journal of Biological Chemistry, 263 (30), 1988, pp. 15634-15642). It is now known that, in addition to the 28 kDa component, this protein has a 35-60 kDa glycosylated component, the one detected in 1986 by the Benga group.

• Only in 1992, the Agre group suggested that "it is likely that CHIP28 is a functional unit of membrane water channels" (Preston et al., Science 256, 1992, pp. 385-387). In this paper, they cited a paper of Benga et al. from 1983, without mentioning their landmark 1986 paper.

• An invited review of the history of the discovery of water channels proteins was published in September 2003, one month before the Nobel Prize for Chemistry was awarded (Benga, Cell Biology International, 27 (9), 2003, pp. 701-709). The contributions of the Benga group, also mentioned in this review, were overlooked by the Nobel Committee. No mention of the results of Benga and coworkers appeared in the historical description of the discovery of aquaporins that joined the prize announcement.

More informations on the official web site. You can also download the petition in printed format, sign it (at the end of the document you will find the signatures table) and send it by fax to +40 264 594 373.

Thank you very much !





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